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KMID : 1098420080160060402
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 6 p.402 ~ p.408
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Enhancement of Immune Activities of Natural Water-Soluble Sulforaphane by Nano Encapsulation Process
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Ha Ji-Hye
Han Jae-Gun
Jeong Hyang-Suk
Oh Sung-Ho
Kwon Min-Cheol
Choi Young-Beom
Ko Jung-Rim
Lee Hyeon-Yong
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Abstract
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This study was performed to investigate improving immune activities of natural water-soluble sulforaphane extracted from Brassica oleracea var. italica by nano encapsulation process. The nanoparticles of the sulforaphane extracted with ultrasonification process at 60℃ promoted human B and T cell growth, about 7~35% compared to the control. The
secretion of IL-6 and TNF-α from T cells were also enhanced as 2.6 × 10?4 pg/cell and 2.1 × 10?4 pg/cell, respectively, by the adding nano samples. NK cell activation was improved about 8%, compare to the control in adding cultured medium of T cell added nano samples. It was also found that sulforaphane extracted from B. oleracea var. italica had highly inhibitory activity on hyaluronidase as IC50 about 200 ㎍/㎖. It can be concluded that natural water-soluble sulforaphane samples by nano-encapsulation, each size is 200 ㎚, extracted from B. oleracea var. italica has high immune activities through higher efficiency of bio-activation than conventional extracts.
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KEYWORD
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Natural Sulforaphane, Nano-encapsulation, Immune activity, Brassica oleracea var. italica
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